35 Biggest Hits is a two-disc greatest hits album from Toby Keith. It was released on May 6, 2008. The album comprises thirty-four previously recorded tracks (18 tracks on Disc 1 and 17 on Disc 2) from Keith's previous studio albums, as well as the newly recorded track She's a Hottie, which was released to radio in early 2008. The album does not include any material from Keith's 2007 album Big Dog Daddy.
This compilation is the first to span Keith's entire career; it was able to do so because Universal Music Group Nashville owned (either outright or through distribution) the rights to his entire catalog. The album has sold 1,210,900 copies in the United States as of January 2017.